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Integrated histologic and molecular analysis of uterine leiomyosarcoma and 2 benign variants with nuclear atypia

18 Dec 2020

Abstract excerpt

Uterine leiomyosarcoma (LMS) is a rare but deadly disease. Due to poor understanding of the molecular and genetic causes of the disease, the diagnosis of LMS has been based primarily on histology. Nuclear atypia is one of hallmarks in LMS, however, it also occurs in 2 clinically benign variants, including smooth muscle tumors with fumarate hydratase alteration (SMT-FH) and leiomyoma with bizarre nuclei (LM-BN)....

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PMID: 33338329
DOI: 10.1111/cas.14775

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