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Article

Genetic diversity and response to IFN of the NS3 protease gene from clinical strains of the hepatitis C virus.

Archives of virology - 1 Jul 2002

Holland-Staley C A, Kovari L C, Golenberg E M, Pobursky K J, Mayers D L

Abstract excerpt

The N-terminal one-third of the hepatitis C virus nonstructural gene 3 (NS3) codes for a serine protease. To investigate natural genetic diversity of this enzyme a nested PCR reaction was developed to obtain NS3 protease sequence data directly from patient strains. This data was used to determine genetic diversity, phylogenetic and evolutionary rates, and selection of variants by interferon therapy. The potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12111414
DOI: 10.1007/s00705-002-0807-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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