Article
Extent of HCV NS3 protease variability and resistance-associated mutations assessed by next generation sequencing in HCV monoinfected and HIV/HCV coinfected patients.
Virus research - 6 Nov 2013
Bartolini Barbara, Giombini Emanuela, Zaccaro Paola, Selleri Marina, Rozera Gabriella, Abbate Isabella, Comandini Ubaldo Visco, Ippolito Giuseppe, Solmone Mariacarmela, Capobianchi Maria R
Abstract excerpt
HCV quasispecies variability represents the background for the selection of mutations and for the development of drug resistance. Natural aminoacid changes in NS3, associated with reduced protease inhibitor susceptibility, have been observed in treatment-naïve patients. Massively parallel sequencing has been used to analyze NS3 quasispecies in patients infected with HCV genotype 1, naive to anti-HCV treatment,...
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