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Article

Molecular Determinants of GS-9620-Dependent TLR7 Activation.

PloS one - 1 Jan 2016

Rebbapragada Indrani, Birkus Gabriel, Perry Jason, Xing Weimei, Kwon HyockJoo, Pflanz Stefan

Abstract excerpt

GS-9620 is an orally administered agonist of Toll-like receptor (TLR)7 currently being evaluated in clinical studies for the treatment of chronic HBV and HIV patients. GS-9620 has shown antiviral efficacy in preclinical models of chronic hepadnavirus infection in woodchuck as well as chimpanzee. However, the molecular determinants of GS-9620-dependent activation of TLR7 are not well defined. The studies presented...

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Identifiers

PMID: 26784926
DOI: 10.1371/journal.pone.0146835
PMCID: PMC4718629

Genes

TLR7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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