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Article

The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection.

Journal of hepatology - 1 Aug 2015

Gane Edward J, Lim Young-Suk, Gordon Stuart C, Visvanathan Kumar, Sicard Eric, Fedorak Richard N, Roberts Stuart, Massetto Benedetta, Ye Zhishen, Pflanz Stefan, Garrison Kimberly L, Gaggar Anuj, Mani Subramanian G, McHutchison John G, Kottilil Shyamasundaran, Freilich Bradley, Coffin Carla S, Cheng Wendy, Kim Yoon Jun

Abstract excerpt

BACKGROUND & AIMS: GS-9620 is an oral agonist of toll-like receptor 7, a pattern-recognition receptor whose activation results in innate and adaptive immune stimulation. We evaluated the safety, pharmacokinetics, and pharmacodynamics of GS-9620 in patients with chronic hepatitis B. METHODS: In two double-blind, phase 1b trials of identical design, 49 treatment-naïve and 51 virologically suppressed patients were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25733157
DOI: 10.1016/j.jhep.2015.02.037

Genes

ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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