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Article

Identification of gp96 as a novel target for treatment of autoimmune disease in mice.

PloS one - 23 Mar 2010

Han Jung Min, Kwon Nam Hoon, Lee Jin Young, Jeong Seung Jae, Jung Hee Jung, Kim Hyeong Rae, Li Zihai, Kim Sunghoon

Abstract excerpt

Heat shock proteins have been implicated as endogenous activators for dendritic cells (DCs). Chronic expression of heat shock protein gp96 on cell surfaces induces significant DC activations and systemic lupus erythematosus (SLE)-like phenotypes in mice. However, its potential as a therapeutic target against SLE remains to be evaluated. In this work, we conducted chemical approach to determine whether SLE-like...

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Identifiers

PMID: 20352117
DOI: 10.1371/journal.pone.0009792
PMCID: PMC2843739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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