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Article

Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor.

The Journal of biological chemistry - 14 Feb 2003

Casarosa Paola, Menge Wiro M, Minisini Rosalba, Otto Claas, van Heteren Jane, Jongejan Aldo, Timmerman Henk, Moepps Barbara, Kirchhoff Frank, Mertens Thomas, Smit Martine J, Leurs Rob

Abstract excerpt

Human cytomegalovirus (HCMV) encodes a G protein-coupled receptor (GPCR), named US28, which shows homology to chemokine receptors and binds several chemokines with high affinity. US28 induces migration of smooth muscle cells, a feature essential for the development of atherosclerosis, and may serve as a co-receptor for human immunodeficiency virus-type 1 entry into cells. Previously, we have shown that...

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PMID: 12456673
DOI: 10.1074/jbc.M210033200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor.PMID 12456673Read ↗

Human Cytomegalovirus US28: A Functionally Selective Chemokine Binding ReceptorSemantic proximity Read ↗

US28: HCMV’s Swiss Army KnifeSemantic proximity Read ↗

The carboxy-terminal tail of human cytomegalovirus (HCMV) US28 regulates both chemokine-independent and chemokine-dependent signaling in HCMV-infected cells.Semantic proximity Read ↗

CC and CX3C Chemokines Differentially Interact with the N Terminus of the Human Cytomegalovirus-encoded US28 ReceptorSemantic proximity Read ↗

Human cytomegalovirus open reading frame US28 encodes a functional beta chemokine receptor.Semantic proximity Read ↗

G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.Semantic proximity Read ↗

Heteromerization of human cytomegalovirus encoded chemokine receptorsSemantic proximity Read ↗

Functional Analysis of the Human Cytomegalovirus US28 Gene by Insertion Mutagenesis with the Green Fluorescent Protein GeneSemantic proximity Read ↗

Plasma membrane rather than endosomal Gq signaling drives transcriptional activity by the viral chemokine receptor US28 in glioblastomaSemantic proximity Read ↗

Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis.Semantic proximity Read ↗

The Human Cytomegalovirus Chemokine Receptor US28 Mediates Vascular Smooth Muscle Cell MigrationSemantic proximity Read ↗

Functional analysis of human cytomegalovirus pUS28 mutants in infected cells.Semantic proximity Read ↗

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