Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins.

Nature communications - 12 Dec 2014

Yuan Wei, Xia Yudong, Bell Christopher G, Yet Idil, Ferreira Teresa, Ward Kirsten J, Gao Fei, Loomis A Katrina, Hyde Craig L, Wu Honglong, Lu Hanlin, Liu Yuan, Small Kerrin S, Viñuela Ana, Morris Andrew P, Berdasco María, Esteller Manel, Brosnan M Julia, Deloukas Panos, McCarthy Mark I, John Sally L, Bell Jordana T, Wang Jun, Spector Tim D

Abstract excerpt

DNA methylation has a great potential for understanding the aetiology of common complex traits such as Type 2 diabetes (T2D). Here we perform genome-wide methylated DNA immunoprecipitation sequencing (MeDIP-seq) in whole-blood-derived DNA from 27 monozygotic twin pairs and follow up results with replication and integrated omics analyses. We identify predominately hypermethylated T2D-related differentially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspases
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenomics

Share to Genetic Loci

Share to Insulin

Share to Protein Kinase C beta

Share to Receptors, G-Protein-Coupled

Share to Twins, Monozygotic

Source

Open in PubMed Open full text

Identifiers

PMID: 25502755
DOI: 10.1038/ncomms6719
PMCID: PMC4284644

Genes

GPR61
MALT1
PRKCB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins.PMID 25502755Read ↗

Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications.Semantic proximity Read ↗

Elucidating the Epigenetic Landscape of Type 2 Diabetes: A Multi-Omics Analysis Revealing Novel CpG Sites and Their Association with Cardiometabolic TraitsSemantic proximity Read ↗

Increased DNA methylation variability in type 1 diabetes across three immune effector cell typesSemantic proximity Read ↗

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.Semantic proximity Read ↗

Network analysis after epigenome wide methylation study revealed JUP as a regulator of co-methylated risk-module for T2DMSemantic proximity Read ↗

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.Semantic proximity Read ↗

DNA Methylation as a Diagnostic and Therapeutic Target in the Battle Against Type 2 DiabetesSemantic proximity Read ↗

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.Semantic proximity Read ↗

Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes.Semantic proximity Read ↗

Multi-omics characterization of type 2 diabetes associated genetic variationSemantic proximity Read ↗

Novel epigenetic determinants of type 2 diabetes in Mexican-American families.Semantic proximity Read ↗

Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes PathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.