Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

PLoS genetics - 1 Sept 2011

Rakyan Vardhman K, Beyan Huriya, Down Thomas A, Hawa Mohammed I, Maslau Siarhei, Aden Deeqo, Daunay Antoine, Busato Florence, Mein Charles A, Manfras Burkhard, Dias Kerith-Rae M, Bell Christopher G, Tost Jörg, Boehm Bernhard O, Beck Stephan, Leslie R David

Abstract excerpt

Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ∼50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease. Although significant progress has been made in elucidating the genetics of T1D in recent years, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CpG Islands
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Epigenomics

Share to Lipopolysaccharide Receptors

Share to Monocytes

Share to Twins, Monozygotic

Source

Open in PubMed Open full text

Identifiers

PMID: 21980303
DOI: 10.1371/journal.pgen.1002300
PMCID: PMC3183089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21980303-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.PMID 21980303Read ↗

Increased DNA methylation variability in type 1 diabetes across three immune effector cell typesSemantic proximity Read ↗

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology.Semantic proximity Read ↗

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes.Semantic proximity Read ↗

Longitudinal DNA methylation differences precede type 1 diabetesSemantic proximity Read ↗

Genetic and epigenetic factors in etiology of diabetes mellitus type 1.Semantic proximity Read ↗

Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications.Semantic proximity Read ↗

Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins.Semantic proximity Read ↗

Genetic and Epigenetic Aspects of Type 1 Diabetes Mellitus: Modern View on the ProblemSemantic proximity Read ↗

CpG methylation changes associated with hyperglycemia in type 1 diabetes occur at angiogenic glomerular and retinal gene lociSemantic proximity Read ↗

Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes.Semantic proximity Read ↗

Epigenetic Modifications and Their Role in Type 1 Diabetes Development: A Review.Semantic proximity Read ↗

Early DNA methylation changes in children developing beta cell autoimmunity at a young ageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.