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Article

Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

PLoS genetics - 1 Sept 2011

Rakyan Vardhman K, Beyan Huriya, Down Thomas A, Hawa Mohammed I, Maslau Siarhei, Aden Deeqo, Daunay Antoine, Busato Florence, Mein Charles A, Manfras Burkhard, Dias Kerith-Rae M, Bell Christopher G, Tost Jörg, Boehm Bernhard O, Beck Stephan, Leslie R David

Abstract excerpt

Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ∼50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease. Although significant progress has been made in elucidating the genetics of T1D in recent years, the non-genetic component has remained poorly defined. We hypothesized that epigenetic variation could underlie some of the...

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Identifiers

PMID: 21980303
DOI: 10.1371/journal.pgen.1002300
PMCID: PMC3183089

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Source receipt: pubmed, retrieved 7 Sept 2026.

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