Article
The analysis of DKK1 polymorphisms in relation to skeletal phenotypes and bone response to alendronate treatment in Chinese postmenopausal women.
Pharmacogenomics - 1 Feb 2016
Wang Jian-yi, Zhou Pei-ran, Liu Yi, Xu Xiao-jie, Ma Dou-dou, Xia Wei-bo, Jiang Yan, Wang Ou, Xing Xiao-ping, Li Mei
Abstract excerpt
AIM: To investigate the correlation between DKK1 polymorphisms with bone phenotypes and response to alendronate treatment. MATERIALS & METHODS: Five tag single nucleotide polymorphisms of DKK1 were analyzed in 639 Chinese postmenopausal women with osteoporosis or osteopenia. Bone mineral density (BMD), β-CTX and ALP were measured before and after alendronate treatment. RESULTS: Genotypes at rs1896367, rs1528877...
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