Genotypic Analyses of the Sclerostin rs851056 and Dickkopf rs1569198 Polymorphisms in Mexican-Mestizo Postmenopausal Osteoporosis: A Case-Control Study.

doi:10.1089/gtmb.2020.0199

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Article

Genotypic Analyses of the Sclerostin rs851056 and Dickkopf rs1569198 Polymorphisms in Mexican-Mestizo Postmenopausal Osteoporosis: A Case-Control Study.

Genetic testing and molecular biomarkers - 1 Mar 2021

Vazquez-Villegas Maria L, Rodriguez-Jimenez Norma A, Contreras-Haro Betsabe, Vasquez-Jimenez Jose C, Perez-Guerrero Edsaul E, Moran-Moguel Maria-Cristina, Sánchez-Rodríguez Esther N, Villagómez-Vega Alejandra, Nuño-Arana Ismael, Becerra-Alvarado Itzel N, Rubio-Arellano Edy D, Nava-Valdivia Cesar A, Ponce-Guarneros Juan M, Fajardo-Robledo Nicte S, Nava-Zavala Arnulfo H, Gonzalez-Lopez Laura, Saldaña-Cruz Ana M

Abstract excerpt

Background: The Wnt/β catenin pathway promotes bone mineralization stimulating proliferation, differentiation, and survival of osteoblasts; it also inhibits osteoclast differentiation and osteocyte activity. Sclerostin (SOST) and Dickkopf 1 (DKK1) are Wnt/β catenin pathway inhibitors. Genetic variability in the expression of SOST and DKK1 might be involved in the development of postmenopausal osteoporosis (OP)....

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PMID: 33734895
DOI: 10.1089/gtmb.2020.0199

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