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OPG, RANKL, and RANK gene polymorphisms and the bone mineral density response to alendronate therapy in postmenopausal Chinese women with osteoporosis or osteopenia.

Pharmacogenetics and genomics - 1 Jan 2016

Zheng Hui, Wang Chun, He Jin-Wei, Fu Wen-Zhen, Zhang Zhen-Lin

Abstract excerpt

OBJECTIVE: The aim of the study was to explore the association between OPG, RANKL, and RANK gene variations and the bone mineral density (BMD) response to alendronate therapy in postmenopausal Chinese women with osteoporosis or osteopenia. MATERIALS AND METHODS: In the present study, 40 single-nucleotide polymorphisms (SNPs) in the OPG, RANKL, and RANK genes were genotyped in 501 postmenopausal Chinese women with...

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PMID: 26426211
DOI: 10.1097/FPC.0000000000000181

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