Article
Common genetic variation in the DKK1 gene is associated with hip axis length but not with bone mineral density and bone turnover markers in young adult men: results from the Odense Androgen Study.
Calcified tissue international - 1 Apr 2010
Piters Elke, Balemans Wendy, Nielsen Torben Leo, Andersen Marianne, Boudin Eveline, Brixen Kim, Van Hul Wim
Abstract excerpt
LRP5 was recently confirmed as an important susceptibility gene for osteoporosis. Our objective was to evaluate the effect of DKK1 polymorphisms on bone mineral density (BMD), hip geometry, and bone turnover. DKK1 is a secreted protein that binds to LRP5/6 receptors and inhibits canonical Wnt sig...
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