Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophage Polarization during MRONJ Development in Mice.

Journal of dental research - 1 Aug 2024

Soundia A, Elzakra N, Hadaya D, Gkouveris I, Bezouglaia O, Dry S, Aghaloo T, Tetradis S

Abstract excerpt

Macrophages are important regulators of bone remodeling, and M1 polarization is observed in the setting of medication-related osteonecrosis of the jaws (MRONJ). Here, we characterize the phenotype of macrophages during early stages of MRONJ development in zoledronate (ZA)-treated mice with periodontal disease and explore the role of rosiglitazone, a drug that has been reported to lower the M1/M2 macrophage ratio,...

Topics

Join the communities discussing this publication.

Thiazolidinediones
X-Ray Microtomography
Bone Density Conservation Agents
Bone Remodeling
Diphosphonates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Matrix Metalloproteinase 13

Periodontal Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 39104155
DOI: 10.1177/00220345241258990
PMCID: PMC11465330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophage Polarization during MRONJ Development in Mice.PMID 39104155Read ↗

Macrophage Polarization in Heterotopic Ossification: Inflammation, Osteogenesis, and Emerging Therapeutic TargetsSemantic proximity Read ↗

Macrophage Polarization and the Regulation of Bone Immunity in Bone HomeostasisSemantic proximity Read ↗

M1 and M2 macrophages markers are alternately expressed during periapical lesion developmentSemantic proximity Read ↗

IL-17–Mediated M1/M2 Macrophage Alteration Contributes to Pathogenesis of Bisphosphonate-Related Osteonecrosis of the JawsSemantic proximity Read ↗

Macrophage polarization in bone implant repair: A review.Semantic proximity Read ↗

Neural epidermal growth factor-like 1 protein (Nell-1) alleviates periodontal tissue destruction in periodontitis by regulating the ratio of M2/M1 macrophage phenotypes.Semantic proximity Read ↗

Macrophages in Bone HomeostasisSemantic proximity Read ↗

Research Advances in Targeted Modulation of Macrophage M1/M2 Polarization for the Treatment of Rheumatoid ArthritisSemantic proximity Read ↗

The role of macrophage polarization in rheumatoid arthritis and osteoarthritis: Pathogenesis and therapeutic strategiesSemantic proximity Read ↗

Macrophage M1/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation.Semantic proximity Read ↗

Targeting different phenotypes of macrophages: A potential strategy for natural products to treat inflammatory bone and joint diseases.Semantic proximity Read ↗

Macrophages regulate the progression of osteoarthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.