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Article

Aberrant Neuregulin 1/ErbB Signaling in Charcot-Marie-Tooth Type 4D Disease.

Molecular and cellular biology - 21 Jul 2022

Jiang Li-Ting, Chen Yu-Hui, Huang Jie-Hong, Tong Wei-Fang, Jin Ling-Jing, Li Li-Xi

Abstract excerpt

Charcot-Marie-Tooth type 4D (CMT4D) is an autosomal recessive demyelinating form of CMT characterized by progressive motor and sensory neuropathy. N-myc downstream regulated gene 1 (NDRG1) is the causative gene for CMT4D. Although more CMT4D cases have been reported, the comprehensive molecular mechanism underlying CMT4D remains elusive. Here, we generated a novel knockout mouse model in which the fourth and...

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Identifiers

PMID: 35708320
DOI: 10.1128/mcb.00559-21
PMCID: PMC9302083

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