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NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states

4 Oct 2007

Abstract excerpt

N-myc downstream-regulated gene 1 (NDRG1) is an intracellular protein that is induced under a wide variety of stress and cell growth-regulatory conditions. NDRG1 is up-regulated by cell differentiation signals in various cancer cell lines and suppresses tumor metastasis. Despite its specific role in the molecular cause of Charcot-Marie-Tooth type 4D disease, there has been more interest in the gene as a marker of...

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PMID: 17916902
DOI: 10.1093/carcin/bgm200

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