Article

Wnt signaling promotes inflammation and EMT-associated gene expression in mesenchymal TNBC

2025-07-10

Abstract excerpt

Aberrant activation of the Wnt signaling pathway in triple-negative breast cancer (TNBC) is linked to treatment resistance and recurrence, yet its role in tumoral heterogeneity remains unclear. We developed Wnt reporter cell lines from two mesenchymal TNBC models (MDA-MB-231 and MDA-MB-436) using a Tcf/Lef-eGFP vector and observed intra- and inter-tumoral variation in Wnt activity. Paired Wnt-positive and Wnt-nega...

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Literature Corpus work: fa7524ba-69ff-5cb3-b27c-2be174b58625
DOI: 10.1101/2025.07.04.663027

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