Article
Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation.
Cancer research - 15 Mar 2017
Cui Ye, Steagall Wendy K, Lamattina Anthony M, Pacheco-Rodriguez Gustavo, Stylianou Mario, Kidambi Pranav, Stump Benjamin, Golzarri Fernanda, Rosas Ivan O, Priolo Carmen, Henske Elizabeth P, Moss Joel, El-Chemaly Souheil
Abstract excerpt
Somatic or germline mutations in the tuberous sclerosis complex (TSC) tumor suppressor genes are associated closely with the pathogenesis of lymphangioleiomyomatosis, a rare and progressive neoplastic disease that predominantly affects women in their childbearing years. Serum levels of the lymphangiogenic growth factor VEGF-D are elevated significantly in lymphangioleiomyomatosis. However, there are gaps in...
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