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Extreme phenotypic diversity in operant response to intravenous cocaine or saline infusion in the hybrid mouse diversity panel.

Addiction biology - 1 May 2022

Bagley Jared R, Khan Arshad H, Smith Desmond J, Jentsch James D

Abstract excerpt

Cocaine self-administration is a complexly determined trait, with a substantial proportion of individual differences being determined by genetic variation. However, the relevant genetic variants that drive heritable differences in cocaine use remain undiscovered. Cocaine intravenous self-administration (IVSA) procedures in laboratory animals provide opportunities to prospectively investigate neurogenetic...

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Cocaine
Cocaine-Related Disorders
Genome-Wide Association Study
Mice
Phenotype

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Self Administration

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PMID: 35470554
DOI: 10.1111/adb.13162
PMCID: PMC9870574

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