Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Genetic Landscape of Ocular Adnexa MALT Lymphoma Reveals Frequent Aberrations in NFAT and MEF2B Signaling Pathways.

Cancer research communications - 1 Oct 2021

Magistri Marco, Happ Lanie E, Ramdial Jeremy, Lu XiaoQing, Stathias Vasileios, Kunkalla Kranthi, Agarwal Nitin, Jiang Xiaoyu, Schürer Stephan C, Dubovy Sander R, Chapman Jennifer R, Vega Francisco, Dave Sandeep, Lossos Izidore S

Abstract excerpt

A comprehensive constellation of somatic non-silent mutations and copy number (CN) variations in ocular adnexa marginal zone lymphoma (OAMZL) is unknown. By utilizing whole-exome sequencing in 69 tumors we define the genetic landscape of OAMZL. Mutations and CN changes in CABIN1 (30%), RHOA (26%), TBL1XR1 (22%), and CREBBP (17%) and inactivation of TNFAIP3 (26%) were among the most common aberrations. Candidate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eye Neoplasms
Share to Lymphoma, B-Cell, Marginal Zone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MEF2 Transcription Factors

Share to Mutation

Share to NF-kappa B

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 35528192
DOI: 10.1158/2767-9764.crc-21-0022
PMCID: PMC9075502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Genetic Landscape of Ocular Adnexa MALT Lymphoma Reveals Frequent Aberrations in NFAT and MEF2B Signaling Pathways.PMID 35528192Read ↗

The mutational landscape of ocular marginal zone lymphoma identifies frequent alterations in TNFAIP3 followed by mutations in TBL1XR1 and CREBBP.Semantic proximity Read ↗

Comprehensive genomic profiling of orbital and ocular adnexal lymphomas identifies frequent alterations in MYD88 and chromatin modifiers: new routes to targeted therapies.Semantic proximity Read ↗

TBL1XR1 Mutations in Primary Marginal Zone Lymphomas of Ocular Adnexa are Associated with Unique Morphometric Phenotypes.Semantic proximity Read ↗

Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas.Semantic proximity Read ↗

Surveying the Genomic Landscape of Mantle Cell Lymphoma Indicates the Importance of Multimodal Genomic and Transcriptomic ExplorationSemantic proximity Read ↗

Genetic heterogeneity of diffuse large B-cell lymphoma.Semantic proximity Read ↗

Detection of new drivers of frequent B-cell lymphoid neoplasms using an integrated analysis of whole genomes.Semantic proximity Read ↗

Comprehensive Genetic Profiling Reveals Frequent Alterations of Driver Genes on the X Chromosome in Extranodal NK/T-cell Lymphoma.Semantic proximity Read ↗

Coding and non-coding drivers of mantle cell lymphoma identified through exome and genome sequencingSemantic proximity Read ↗

High throughput sequencing reveals high specificity of TNFAIP3 mutations in ocular adnexal marginal zone B-cell lymphomas.Semantic proximity Read ↗

Comparative genome profiling across subtypes of low-grade B-cell lymphoma identifies type-specific and common aberrations that target genes with a role in B-cell neoplasiaSemantic proximity Read ↗

Mutation analysis of NF-κB signal pathway-related genes in ocular MALT lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.