Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma.

Cancer cell - 14 Dec 2010

Calado Dinis Pedro, Zhang Baochun, Srinivasan Lakshmi, Sasaki Yoshiteru, Seagal Jane, Unitt Christine, Rodig Scott, Kutok Jeffery, Tarakhovsky Alexander, Schmidt-Supprian Marc, Rajewsky Klaus

Abstract excerpt

Diffuse large B cell lymphoma (DLBCL) comprises disease entities with distinct genetic profiles, including germinal center B cell (GCB)-like and activated B cell (ABC)-like DLBCLs. Major differences between these two subtypes include genetic aberrations leading to constitutive NF-κB activation and interference with terminal B cell differentiation through BLIMP1 inactivation, observed in ABC- but not GCB-DLBCL....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Germinal Center

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to I-kappa B Kinase

Share to Lymphoma, Large B-Cell, Diffuse

Share to NF-kappa B

Share to Plasma Cells

Share to Positive Regulatory Domain I-Binding Factor 1

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21156282
DOI: 10.1016/j.ccr.2010.11.024
PMCID: PMC3018685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma.PMID 21156282Read ↗

Rewired NFκB signaling as a potentially actionable feature of activated B-cell-like diffuse large B-cell lymphoma.Semantic proximity Read ↗

PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomasSemantic proximity Read ↗

Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation.Semantic proximity Read ↗

B-cell–specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in miceSemantic proximity Read ↗

Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.Semantic proximity Read ↗

Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Inducibly Expressing MyD88 L265P Mutation Identifies Upregulated CD44, LGALS3, NFKBIZ, and BATF as Downstream Targets of Oncogenic NF-κB Signaling.Semantic proximity Read ↗

Genetic drivers of NF-κB deregulation in diffuse large B-cell lymphomaSemantic proximity Read ↗

LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells.Semantic proximity Read ↗

Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.Semantic proximity Read ↗

An Oncogenic Role for Alternative NF-κB Signaling in DLBCL Revealed upon Deregulated BCL6 ExpressionSemantic proximity Read ↗

Oncogenically active MYD88 mutations in human lymphoma.Semantic proximity Read ↗

Critical role of PI3K signaling for NF-κB–dependent survival in a subset of activated B-cell–like diffuse large B-cell lymphoma cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.