Article
Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype.
Oncogene - 20 Jul 2017
Guo X, Koff J L, Moffitt A B, Cinar M, Ramachandiran S, Chen Z, Switchenko J M, Mosunjac M, Neill S G, Mann K P, Bagirov M, Du Y, Natkunam Y, Khoury H J, Rossi M R, Harris W, Flowers C R, Lossos I S, Boise L H, Dave S S, Kowalski J, Bernal-Mizrachi L
Abstract excerpt
Diffuse large B-cell lymphoma (DLBCL) has been categorized into two molecular subtypes that have prognostic significance, namely germinal center B-cell like (GCB) and activated B-cell like (ABC). Although ABC-DLBCL has been associated with NF-κB activation, the relationships between activation of specific NF-κB signals and DLBCL phenotype remain unclear. Application of novel gene expression classifiers identified...
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