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Article

Dominant negative consequences of a hERG 1b-specific mutation associated with intrauterine fetal death.

Progress in biophysics and molecular biology - 1 Jan 2016

Jones David K, Liu Fang, Dombrowski Natasha, Joshi Sunita, Robertson Gail A

Abstract excerpt

The human ether-a-go-go related gene (hERG) encodes two subunits, hERG 1a and hERG 1b, that combine in vivo to conduct the rapid delayed rectifier potassium current (IKr). Reduced IKr slows cardiac action potential (AP) repolarization and is an underlying cause of cardiac arrhythmias associated with long QT syndrome (LQTS). Although the physiological importance of hERG 1b has been elucidated, the effects of hERG...

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Identifiers

PMID: 26772437
DOI: 10.1016/j.pbiomolbio.2016.01.002
PMCID: PMC4821159

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