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Article

The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia.

Cell reports - 26 Jan 2016

Shen Kimberle, Sidik Harwin, Talbot William S

Abstract excerpt

Microglia are resident macrophages of the CNS that are essential for phagocytosis of apoptotic neurons and weak synapses during development. We show that RagA and Lamtor4, two components of the Rag-Ragulator complex, are essential regulators of lysosomes in microglia. In zebrafish lacking RagA function, microglia exhibit an expanded lysosomal compartment, but they are unable to properly digest apoptotic neuronal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26774477
DOI: 10.1016/j.celrep.2015.12.055
PMCID: PMC4731305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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