Article

Megalin deficiency perturbs retinal homeostasis and impairs cathepsin D processing and phagosome-lysosome maturation in the retinal pigment epithelium

2026-06-26

Abstract excerpt

The multiligand endocytic receptor, megalin (LRP2), is expressed in the retinal pigment epithelium (RPE) and patients lacking the receptor develop high myopia. Despite its established role in retinal development, the contribution of megalin to retinal homeostasis in the normally developed/mature eye remains poorly understood. Here, we investigated megalin function using an inducible knockout mouse (KO) model and h...

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Literature Corpus work: 399120fe-38d0-53a4-9c73-1022afad9fe4
DOI: 10.64898/2026.06.26.734689

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