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Article

mTOR activity is essential for retinal pigment epithelium regeneration in zebrafish

10 Mar 2022

Abstract excerpt

The retinal pigment epithelium (RPE) plays numerous critical roles in maintaining vision and this is underscored by the prevalence of degenerative blinding diseases like age-related macular degeneration (AMD), in which visual impairment is caused by progressive loss of RPE cells. In contrast to mammals, zebrafish possess the ability to intrinsically regenerate a functional RPE layer after severe injury. The...

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PMID: 35271573
DOI: 10.1371/journal.pgen.1009628

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