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Article

Increased Plasma Homocysteine Level is Associated with Executive Dysfunction in Type 2 Diabetic Patients with Mild Cognitive Impairment.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Tian Sai, Han Jing, Huang Rong, Sun Jie, Cai Rongrong, Shen Yanjue, Wang Shaohua

Abstract excerpt

BACKGROUND: Homocysteine (Hcy) is involved in the pathogenesis of type 2 diabetes mellitus (T2DM) and Alzheimer's disease. OBJECTIVE: We aimed to investigate the role of Hcy in T2DM patients with mild cognitive impairment (MCI), and to determine whether methylene tetrahydrofolate reductase (MTHFR) C677T or cystathionine beta-synthase (CBS) 844ins68 polymorphism is related to T2DM-associated MCI. METHODS: We...

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PMID: 28550262
DOI: 10.3233/JAD-170162

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CBS
MTHFR

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