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Article

Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women.

American journal of epidemiology - 15 Sept 2007

Elkins Jacob S, Johnston S Claiborne, Ziv Elad, Kado Deborah, Cauley Jane A, Yaffe Kristine

Abstract excerpt

Homocysteine may play a causal role in cognitive decline. The authors analyzed the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotype, a correlate of plasma homocysteine levels, among 6,653 participants in the Study of Osteoporotic Fractures, a community-based, prospective cohort study of older women in four US states. During the years 1986-1998, the authors assessed whether the distribution of MTHFR...

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Identifiers

PMID: 17638709
DOI: 10.1093/aje/kwm140

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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