Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women.

American journal of epidemiology - 15 Sept 2007

Elkins Jacob S, Johnston S Claiborne, Ziv Elad, Kado Deborah, Cauley Jane A, Yaffe Kristine

Abstract excerpt

Homocysteine may play a causal role in cognitive decline. The authors analyzed the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotype, a correlate of plasma homocysteine levels, among 6,653 participants in the Study of Osteoporotic Fractures, a community-based, prospective cohort stu...

Topics

Aged
Aged, 80 and over
Chi-Square Distribution
Cognition Disorders
Female
Genetic Predisposition to Disease
Genotype
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Osteoporosis, Postmenopausal
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prospective Studies

Regression Analysis

Statistics, Nonparametric

United States

Source

Identifiers

PMID: 17638709
DOI: 10.1093/aje/kwm140

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-17638709-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women.PMID 17638709Read ↗

Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians.Semantic proximity Read ↗

Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the health in men study.Semantic proximity Read ↗

Folate and the methylenetetrahydrofolate reductase 677C-->T mutation correlate with cognitive performance.Semantic proximity Read ↗

High homocysteine and epistasis between MTHFR and APOE: association with cognitive performance in the elderly.Semantic proximity Read ↗

Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis.Semantic proximity Read ↗

Homocysteine and the methylenetetrahydrofolate reductase 677C-->T polymorphism in relation to muscle mass and strength, physical performance and postural sway.Semantic proximity Read ↗

The C677T variant in MTHFR modulates associations between blood-based and cerebrospinal fluid biomarkers of neurodegeneration.Semantic proximity Read ↗

The effects of homocysteine and MTHFR genotype on hip bone loss and fracture risk in elderly women.Semantic proximity Read ↗

The sex-specific effect of the apolipoprotein E allele and methylenetetrahydrofolate reductase gene polymorphism on the biochemical, anatomical, and cognitive profiles of patients clinically diagnosed with probable Alzheimer's disease.Semantic proximity Read ↗

Folate Pathway Gene Methylenetetrahydrofolate Reductase C677T Polymorphism and Alzheimer Disease Risk in Asian PopulationSemantic proximity Read ↗

Plasma homocysteine and MTHFRC677T polymorphism as risk factors for incident dementia.Semantic proximity Read ↗

Status of Vitamins B-12 and B-6 but Not of Folate, Homocysteine, and the Methylenetetrahydrofolate Reductase C677T Polymorphism Are Associated with Impaired Cognition and Depression in AdultsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.