Article
Reducing GWAS Complexity.
Cell cycle (Georgetown, Tex.) - 1 Jan 2016
Hazelett Dennis J, Conti David V, Han Ying, Al Olama Ali Amin, Easton Doug, Eeles Rosalind A, Kote-Jarai Zsofia, Haiman Christopher A, Coetzee Gerhard A
Abstract excerpt
Genome-wide association studies (GWAS) have revealed numerous genomic 'hits' associated with complex phenotypes. In most cases these hits, along with surrogate genetic variation as measure by numerous single nucleotide polymorphisms (SNPs) that are in linkage disequilibrium, are not in coding genes making assignment of functionality or causality intractable. Here we propose that fine-mapping along with the...
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