Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantation.

doi:10.1016/j.bbmt.2007.09.012

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Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Jan 2008

Yabe Toshio, Matsuo Keitaro, Hirayasu Kouyuki, Kashiwase Koichi, Kawamura-Ishii Sumiyo, Tanaka Hidenori, Ogawa Atsuko, Takanashi Minoko, Satake Masahiro, Nakajima Kazunori, Tokunaga Katsushi, Inoko Hidetoshi, Saji Hiroo, Ogawa Seishi, Juji Takeo, Sasazuki Takehiko, Kodera Yoshihisa, Morishima Yasuo

Abstract excerpt

We previously reported the potent adverse effects of killer immunoglobulin-like receptor (KIR) ligand mismatch (KIR-L-MM) on the outcome of T cell-replete unrelated hematopoietic stem cell transplantation (UR-HSCT) through the Japan Marrow Donor Program. Other UR-HSCT studies have yielded inconsistent results. To address this discrepancy, we evaluated candidate factors contributing to the effects of KIR-L-MM on...

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PMID: 18158964
DOI: 10.1016/j.bbmt.2007.09.012

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