Article
Prevalence and Characterization of Heterogeneous Variable-Number Tandem-Repeat Clusters Comprising Drug-Susceptible and/or Variable Resistant Mycobacterium tuberculosis Complex Isolates in the Netherlands from 2004 to 2016.
Journal of clinical microbiology - 1 Nov 2018
Roof Inge, Jajou Rana, Kamst Miranda, Mulder Arnout, de Neeling Albert, van Hunen Rianne, van der Hoek Wim, van Soolingen Dick
Abstract excerpt
The variable-number tandem-repeat (VNTR) typing method is used to study tuberculosis (TB) transmission. Clustering of Mycobacterium tuberculosis isolates with identical VNTR patterns is assumed to reflect recent transmission. Hence, clusters are thought to be homogeneous regarding antibiotic resistance. In practice, however, heterogeneous clusters are also identified. This study investigates the prevalence and...
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