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Article

Functional single nucleotide polymorphism in IL-17A 3' untranslated region is targeted by miR-4480 in vitro and may be associated with age-related macular degeneration.

Environmental and molecular mutagenesis - 1 Jan 2016

Popp Nicholas A, Yu Dianke, Green Bridgett, Chew Emily Y, Ning Baitang, Chan Chi-Chao, Tuo Jingsheng

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss in the elderly. Genetic factors contributing to AMD include single nucleotide polymorphisms (SNPs) in immune-related genes including CFH, C2, CFI, C9, and C3, thus implicating these pathways in AMD pathogenesis. MicroRNAs (miRNAs) are powerful regulators of gene expression and execute this function by binding to the 3'...

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3' Untranslated Regions
Epistasis, Genetic
Interleukin-17
Linkage Disequilibrium
Macular Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Interference

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Open in PubMed Open full text

Identifiers

PMID: 26765636
DOI: 10.1002/em.21982
PMCID: PMC4714768

Genes

CFH
CFI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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