Article
Hypomethylation of the IL17RC promoter associates with age-related macular degeneration.
Cell reports - 29 Nov 2012
Wei Lai, Liu Baoying, Tuo Jingsheng, Shen Defen, Chen Ping, Li Zhiyu, Liu Xunxian, Ni Jia, Dagur Pradeep, Sen H Nida, Jawad Shayma, Ling Diamond, Park Stanley, Chakrabarty Sagarika, Meyerle Catherine, Agron Elvira, Ferris Frederick L, Chew Emily Y, McCoy J Philip, Blum Emily, Francis Peter J, Klein Michael L, Guymer Robyn H, Baird Paul N, Chan Chi-Chao, Nussenblatt Robert B
Abstract excerpt
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs in a number of genes, other modes of regulation are also likely to play a role in the etiology of this disease. We identified a significantly decreased level of methylation on the IL17RC promoter in AMD...
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