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Genetic variants in microRNAs and their binding sites within gene 3'UTRs associate with susceptibility to age-related macular degeneration.

Human mutation - 1 Jul 2017

Ghanbari Mohsen, Erkeland Stefan J, Xu Lei, Colijn Johanna M, Franco Oscar H, Dehghan Abbas, Klaver Caroline C W, Meester-Smoor Magda A

Abstract excerpt

Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is a complex disease that results from multiple genetic and environmental factors. MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate target mRNAs and are frequently implicated in human diseases. Here, we investigated the association of genetic variants in miRNAs and miRNA-binding sites within gene...

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3' Untranslated Regions
A549 Cells
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Complement C3
Complement Factor B

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Macular Degeneration

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PMID: 28397307
DOI: 10.1002/humu.23226

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CFB

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