Genetic variants and serum biomarkers of CXCL8, MAP3K7, LTA/TNF, EXOC3L1, PROCR, and TRAF2 in Age-Related macular degeneration: associations with disease risk and therapeutic response.

doi:10.1038/s41598-026-42838-9

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Genetic variants and serum biomarkers of CXCL8, MAP3K7, LTA/TNF, EXOC3L1, PROCR, and TRAF2 in Age-Related macular degeneration: associations with disease risk and therapeutic response.

Scientific reports - 17 Mar 2026

Cebatoriene Dzastina, Vilkeviciute Alvita, Duseikaite-Vidike Monika, Pileckaite Enrika, Bruzaite Akvile, Kriauciuniene Loresa, Zaliuniene Dalia, Liutkeviciene Rasa

Abstract excerpt

Since age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in the aging population, it is a significant global health concern. Although anti-vascular endothelial growth factor (anti-VEGF) treatments are effective, not all patients respond to them fully. This study focuses on key single-nucleotide variants in the CXCL8 (rs2227306), MAP3K7 (rs157432), LTA/TNF (rs2229094),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

TNF Receptor-Associated Factor 2

Tumor Necrosis Factor-alpha

Vascular Endothelial Growth Factor A

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Identifiers

PMID: 41844873
DOI: 10.1038/s41598-026-42838-9
PMCID: PMC13129072

Genes

CXCL8
EXOC3L1
LTA
MAP3K7
PROCR
TNF
TRAF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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