Article
Interleukin-1β-31 (rs1143627) genetic variant and the risk of age-related macular degeneration in the Brazilian population.
Ophthalmic genetics - 1 Oct 2021
Makita Lana Sayuri, Muniz Bernardo Carvalho, da Silva Alícia Buffoni Roque, Bajano Flávia Fialho, Hirata Fábio Endo, do Amaral Marcelo, Rim Priscila Hae Hyun, de Carvalho-Siqueira Gabriela Queila, Cabral de Vasconcellos José Paulo, de Melo Mônica Barbosa, Medina Flávio Mac Cord
Abstract excerpt
Background: Age-related macular degeneration (AMD) is a multifactorial disease and one of the main causes of blindness in people over 50 years old. The etiology and pathophysiology of AMD are not well understood. The aim of this study was to investigate whether the rs1143627 variant allele of IL1B, which encodes Interleukin (IL)-1β, a key cytokine, mediates immune and inflammatory responses.Methods: A...
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