Article
Mitochondrial anchorage and fusion contribute to mitochondrial inheritance and quality control in the budding yeast Saccharomyces cerevisiae.
Molecular biology of the cell - 1 Mar 2016
Higuchi-Sanabria Ryo, Charalel Joseph K, Viana Matheus P, Garcia Enrique J, Sing Cierra N, Koenigsberg Andrea, Swayne Theresa C, Vevea Jason D, Boldogh Istvan R, Rafelski Susanne M, Pon Liza A
Abstract excerpt
Higher-functioning mitochondria that are more reduced and have less ROS are anchored in the yeast bud tip by the Dsl1-family protein Mmr1p. Here we report a role for mitochondrial fusion in bud-tip anchorage of mitochondria. Fluorescence loss in photobleaching (FLIP) and network analysis experiments revealed that mitochondria in large buds are a continuous reticulum that is physically distinct from mitochondria...
Topics
- DNA, Mitochondrial
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Green Fluorescent Proteins
- Membrane Proteins
- Mitochondria
- Mitochondrial Dynamics
- Mitochondrial Proteins
- Mutation
- Photobleaching
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins