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Article

The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast.

The Journal of cell biology - 8 Aug 2011

Förtsch Johannes, Hummel Eric, Krist Melanie, Westermann Benedikt

Abstract excerpt

The inheritance of mitochondria in yeast depends on bud-directed transport along actin filaments. It is a matter of debate whether anterograde mitochondrial movement is mediated by the myosin-related motor protein Myo2 or by motor-independent mechanisms. We show that mutations in the Myo2 cargo binding domain impair entry of mitochondria into the bud and are synthetically lethal with deletion of the YPT11 gene...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21807878
DOI: 10.1083/jcb.201012088
PMCID: PMC3153652

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast.PMID 21807878Read ↗

A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division.Semantic proximity Read ↗

Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae.Semantic proximity Read ↗

Fusion, fission, and transport control asymmetric inheritance of mitochondria and protein aggregates.Semantic proximity Read ↗

Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast.Semantic proximity Read ↗

Two distinct regions in a yeast myosin-V tail domain are required for the movement of different cargoes.Semantic proximity Read ↗

The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles.Semantic proximity Read ↗

Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion.Semantic proximity Read ↗

Actin-dependent mitochondrial motility in mitotic yeast and cell-free systems: identification of a motor activity on the mitochondrial surface.Semantic proximity Read ↗

The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting.Semantic proximity Read ↗

The tail of a yeast class V myosin, myo2p, functions as a localization domain.Semantic proximity Read ↗

Mitochondrial anchorage and fusion contribute to mitochondrial inheritance and quality control in the budding yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae.Semantic proximity Read ↗

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