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Article

Fusion, fission, and transport control asymmetric inheritance of mitochondria and protein aggregates.

The Journal of cell biology - 7 Aug 2017

Böckler Stefan, Chelius Xenia, Hock Nadine, Klecker Till, Wolter Madita, Weiss Matthias, Braun Ralf J, Westermann Benedikt

Abstract excerpt

Partitioning of cell organelles and cytoplasmic components determines the fate of daughter cells upon asymmetric division. We studied the role of mitochondria in this process using budding yeast as a model. Anterograde mitochondrial transport is mediated by the myosin motor, Myo2. A genetic screen revealed an unexpected interaction of MYO2 and genes required for mitochondrial fusion. Genetic analyses, live-cell...

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Identifiers

PMID: 28615194
DOI: 10.1083/jcb.201611197
PMCID: PMC5551707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fusion, fission, and transport control asymmetric inheritance of mitochondria and protein aggregates.PMID 28615194Read ↗

The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast.Semantic proximity Read ↗

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Mitochondrial transport, partitioning, and quality control at the heart of cell proliferation and fate acquisition.Semantic proximity Read ↗

Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion.Semantic proximity Read ↗

Mitochondrial anchorage and fusion contribute to mitochondrial inheritance and quality control in the budding yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division.Semantic proximity Read ↗

Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast.Semantic proximity Read ↗

Significantly reduced, but balanced, rates of mitochondrial fission and fusion are sufficient to maintain the integrity of yeast mitochondrial DNA.Semantic proximity Read ↗

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Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast.Semantic proximity Read ↗

Steric hindrance in the upper 50 kDa domain of the motor Myo2p leads to cytokinesis defects in fission yeast.Semantic proximity Read ↗

Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae.Semantic proximity Read ↗

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