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Article

Matrix-driven Myosin II Mediates the Pro-fibrotic Fibroblast Phenotype.

The Journal of biological chemistry - 18 Mar 2016

Southern Brian D, Grove Lisa M, Rahaman Shaik O, Abraham Susamma, Scheraga Rachel G, Niese Kathryn A, Sun Huanxing, Herzog Erica L, Liu Fei, Tschumperlin Daniel J, Egelhoff Thomas T, Rosenfeld Steven S, Olman Mitchell A

Abstract excerpt

Pro-fibrotic mesenchymal cells are known to be the key effector cells of fibroproliferative disease, but the specific matrix signals and the induced cellular responses that drive the fibrogenic phenotype remain to be elucidated. The key mediators of the fibroblast fibrogenic phenotype were characterized using a novel assay system that measures fibroblast behavior in response to actual normal and fibrotic lung...

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Source

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Identifiers

PMID: 26763235
DOI: 10.1074/jbc.M115.712380
PMCID: PMC4813589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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