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Article

Fibroblasts treated with macrophage conditioned medium results in phenotypic shifts and changes in collagen organization.

Materials science & engineering. C, Materials for biological applications - 1 Mar 2021

Li Zhuqing, Bratlie Kaitlin M

Abstract excerpt

In tissue regeneration, the goal is to regenerate tissue similar to what was damaged or missing while preventing fibrotic scarring, which may lead to decreased mechanical strength and dissimilar tissue characteristics compared to native tissue. We believe collagen orientation plays a critical role in wound contraction and scarring and that it is modulated by myofibroblasts. We used macrophage conditioned medium...

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Identifiers

PMID: 33641908
DOI: 10.1016/j.msec.2021.111915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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