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Article

Regulation of Bax/mitochondria interaction by AKT.

FEBS letters - 1 Jan 2016

Simonyan Lilit, Renault Thibaud T, Novais Maria João da Costa, Sousa Maria João, Côrte-Real Manuela, Camougrand Nadine, Gonzalez Cécile, Manon Stéphen

Abstract excerpt

Bax-dependent mitochondrial permeabilization during apoptosis is controlled by multiple factors, including the phosphorylation by the protein kinase AKT. We used the heterologous co-expression of human Bax and AKT1 in yeast to investigate how the kinase modulates the different steps underlying Bax activation. We found that AKT activated Bax and increased its cellular content. Both effects were dependent on...

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Identifiers

PMID: 26763134
DOI: 10.1002/1873-3468.12030

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AKT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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