Article
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).
The Journal of biological chemistry - 13 Feb 2004
Dan Han C, Sun Mei, Kaneko Satoshi, Feldman Richard I, Nicosia Santo V, Wang Hong-Gang, Tsang Benjamin K, Cheng Jin Q
Abstract excerpt
Akt negatively regulates apoptotic pathways at a premitochondrial level through phosphorylation and modulation of proteins such as Bad, Forkhead proteins, and GSK-3beta. Akt has also been shown to protect cell death at a post-mitochondrial level, although its downstream targets have not been well documented. Here, we demonstrate that Akt, including AKT1 and AKT2, interacts with and phosphorylates X-linked...
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