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Article

Mono- or double-site phosphorylation distinctly regulates the proapoptotic function of Bax.

PloS one - 14 Oct 2010

Wang Qinhong, Sun Shi-Yong, Khuri Fadlo, Curran Walter J, Deng Xingming

Abstract excerpt

Bax is the major multidomain proapoptotic molecule that is required for apoptosis. It has been reported that phosphorylation of Bax at serine(S) 163 or S184 activates or inactivates its proapoptotic function, respectively. To uncover the mechanism(s) by which phosphorylation regulates the proapoptotic function of Bax, a series of serine (S)→ alanine/glutamate (A/E) Bax mutants, including S163A, S184A, S163E,...

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Share to Apoptosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20976235
DOI: 10.1371/journal.pone.0013393
PMCID: PMC2954808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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