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Article

Umbilical cord-derived mesenchymal stem cells instruct dendritic cells to acquire tolerogenic phenotypes through the IL-6-mediated upregulation of SOCS1.

Stem cells and development - 1 Sept 2014

Deng Yinan, Yi Shuhong, Wang Guoying, Cheng Jintao, Zhang Yingcai, Chen Wenjie, Tai Yan, Chen Shaohong, Chen Guihua, Liu Wei, Zhang Qi, Yang Yang

Abstract excerpt

The mechanisms responsible for the inhibitory effects of mesenchymal stem cells (MSCs) on dendritic cells (DCs) are still poorly understood. Our investigation of the potential signaling pathways revealed for the first time that human umbilical-cord-derived MSCs (UC-MSCs) instruct DCs to acquire tolerogenic phenotypes through the IL-6-mediated upregulation of SOCS1. This subset of MSC-DCs exhibited a tolerogenic...

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Source

Identifiers

PMID: 24730420
DOI: 10.1089/scd.2013.0559

Genes

SOCS1
MSC
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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