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Article

The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.

The Biochemical journal - 15 Mar 2016

Cesnekova Jana, Rodinova Marie, Hansikova Hana, Houstek Josef, Zeman Jiri, Stiburek Lukas

Abstract excerpt

Mitochondrial protein homeostasis is crucial for cellular function and integrity and is therefore maintained by several classes of proteins possessing chaperone and/or proteolytic activities. In the present study, we focused on characterization of LACE1 (lactation elevated 1) function in mitochondrial protein homeostasis. LACE1 is the human homologue of yeast mitochondrial Afg1 (ATPase family gene 1) ATPase, a...

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Identifiers

PMID: 26759378
DOI: 10.1042/BJ20151029

Genes

VCP
NSF
TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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