Article
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.
Nature - 6 Dec 2001
Ye Y, Meyer H H, Rapoport T A
Abstract excerpt
In eukaryotic cells, incorrectly folded proteins in the endoplasmic reticulum (ER) are exported into the cytosol and degraded by the proteasome. This pathway is co-opted by some viruses. For example, the US11 protein of the human cytomegalovirus targets the major histocompatibility complex class I heavy chain for cytosolic degradation. How proteins are extracted from the ER membrane is unknown. In bacteria and...
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