Article

Inactivation of the mitochondrial protease Afg3l2 results in severely diminished respiratory chain activity and widespread defects in mitochondrial gene expression

2020-06-01

Abstract excerpt

The m -AAA proteases plays a critical role in the proteostasis of the inner mitochondrial membrane proteins, and mutations in the genes encoding these proteases cause severe incurable neurological diseases. To further explore the biological role of the m -AAA proteases and the pathological consequences of their deficiency, we used a genetic approach in the fruit fly Drosophila melanogaster to inactivate the ATP...

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Literature Corpus work: ce97b6bc-8ff2-5d57-acf9-25f7170b679e
DOI: 10.1101/2020.05.31.126607

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