Article
The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease.
The EMBO journal - 17 Aug 1998
Arlt H, Steglich G, Perryman R, Guiard B, Neupert W, Langer T
Abstract excerpt
Yta10p (Afg3p) and Yta12p (Rcal1p), members of the conserved AAA family of ATPases, are subunits of the mitochondrial m-AAA protease, an inner membrane ATP-dependent metallopeptidase. Deletion of YTA10 or YTA12 impairs degradation of non-assembled inner membrane proteins and assembly of respirato...
Topics
- Adenosine Triphosphatases
- Cyclooxygenase 1
- Electron Transport
- Electron Transport Complex IV
- Fungal Proteins
- Hydrolysis
- Introns
- Isoenzymes
- Metalloendopeptidases
- Mitochondria
- Mutation
- Phenotype
- Prostaglandin-Endoperoxide Synthases
- Protease Inhibitors
- Protein Processing, Post-Translational