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Article

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.

Scientific reports - 13 Jan 2016

Raman Marine C C, Rizkallah Pierre J, Simmons Ruth, Donnellan Zoe, Dukes Joseph, Bossi Giovanna, Le Provost Gabrielle S, Todorov Penio, Baston Emma, Hickman Emma, Mahon Tara, Hassan Namir, Vuidepot Annelise, Sami Malkit, Cole David K, Jakobsen Bent K

Abstract excerpt

Natural T-cell responses generally lack the potency to eradicate cancer. Enhanced affinity T-cell receptors (TCRs) provide an ideal approach to target cancer cells, with emerging clinical data showing significant promise. Nevertheless, the risk of off target reactivity remains a key concern, as exemplified in a recent clinical report describing fatal cardiac toxicity, following administration of MAGE-A3 specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26758806
DOI: 10.1038/srep18851
PMCID: PMC4725365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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